By Qin Wang
This quantity of present subject matters in Membranes specializes in Adrenergic Receptor Biology, starting with a evaluate of prior successes and historic views then extra discussing present normal tendencies in adrenic receptor reviews in a variety of contexts. This book additionally comprises discussions of the position and dating of adrenergic receptors to varied platforms and illnesses, constructing Adrenergic Receptor Biology as a wanted, functional reference for researchers.
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Extra resources for Advances in Adrenergic Receptor Biology
The majority of drugs that target GPCR signal transduction systems act as either orthosteric agonists, antagonists, or inverse agonists, although allosteric ligands are becoming more important. Therapeutic strategies often require regulating activity of a subset of specific effectors, but drugs aimed at GPCRs coupled to multiple effectors most certainly lack specificity in this regard, and are usually associated with undesirable side effects. , G proteins with a specific subunit composition, effector molecules, or regulatory proteins) suggests that there are correspondingly unique structural determinants involved in signal transduction that might serve as allosteric targets for therapeutic small molecule, peptidic, and/or peptidomimetic drugs with greater specificity and fewer side effects.
J. (1978). Agonist-induced increase in apparent beta-adrenergic receptor size. Proc Natl Acad Sci USA, 75, 228–232. Limbird, L. , Gill, D. , & Lefkowitz, R. J. (1980). Agonist-promoted coupling of the betaadrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proc Natl Acad Sci USA, 77, 775–779. Lohse, M. , Benovic, J. , Caron, M. , & Lefkowitz, R. J. (1990). Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
Limbird, L. , Gill, D. , & Lefkowitz, R. J. (1980). Agonist-promoted coupling of the betaadrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proc Natl Acad Sci USA, 77, 775–779. Lohse, M. , Benovic, J. , Caron, M. , & Lefkowitz, R. J. (1990). Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem, 265, 3202–3211. , & Limbird, L. , (2010). Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilinnull mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor.
Advances in Adrenergic Receptor Biology by Qin Wang