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Antibody-Drug Conjugates: Fundamentals, Drug Development, by Kenneth J. Olivier Jr., Sara A. Hurvitz PDF

By Kenneth J. Olivier Jr., Sara A. Hurvitz

ISBN-10: 1119060680

ISBN-13: 9781119060680

Providing sensible and confirmed recommendations for antibody-drug conjugate (ADC) drug discovery luck in oncology, this ebook is helping readers enhance the drug security and healing efficacy of ADCs to kill exact tumor cells.

• Discusses the fundamentals, drug supply concepts, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case reviews of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC study and development

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Additional info for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Example text

Nature 1975;256:495–7. 3 Harrison JS, Keshavarz‐Moore E. Production of Antibody Fragments in Escherichia coli. Annals of the New York Academy of Sciences 1996;782:143–58. 4 Humphreys DP. Production of antibodies and antibody fragments in 5 6 7 8 9 Escherichia coli and a comparison of their functions, uses and modification. Current Opinion in Drug Discovery and Development 2003;6:188–96. Itakura K, Hirose T, Crea R, et al. Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.

EMERGE: a randomized Phase II study of the antibody‐drug conjugate glembatumumab vedotin in advanced glycoprotein NMB‐expressing breast cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2015;33:1609–19. Pipleline. ) Hamblett KJ, Kozlosky CJ, Siu S, et al. AMG 595, an anti‐EGFRvIII antibody drug conjugate, induces potent anti‐tumor activity against EGFRvIII expressing glioblastoma. Molecular Cancer Therapeutics 2015. 1 Part I What is an Antibody–Drug Conjugate 3 1 Typical Antibody–Drug Conjugates John M.

2 Payloads Targeting Tubulin Although these DNA-acting cytotoxins have the desired attribute of extraordinary high potency to be effective as an ADC payload, such compounds do have drawbacks. , duocarmycins) may not be stable in aqueous environments, thus requiring the use of prodrug approaches to protect the DNA-alkylating function [44]. These factors may explain why, even though the first ADC to receive approval utilized calicheamicin as the payload [35], only 11 of the 51 ADCs in clinical development at the time of writing utilize DNA-targeting compounds as payloads.

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Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer by Kenneth J. Olivier Jr., Sara A. Hurvitz


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