By Martial G. Bourassa, Jean-Claude Tardif
power oxidative tension is linked to the getting older procedure and sometimes ends up in the improvement of issues reminiscent of melanoma and arterial sickness. Cardiovascular stipulations within which oxidation harm has been strongly implicated contain atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive middle failure. Antioxidants and heart problems, moment version covers 3 significant themes: 1) the 1st seven chapters evaluate the oxidative modifcation speculation and its shut dating to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the following 4 chapters describe the various compounds, food and vitamins with antioxidant homes and their mechanisms of motion; three) and finallly, the final ten chapters speak about the capability merits of antioxidants in total cardiovascular prevention, together with high blood pressure, diabetes mellitus, dyslipidemias, and within the remedy and prevention of particular stipulations corresponding to persistent coronary artery affliction, restenosis after percutaneous coronary intervention, and protracted middle failure. Antioxidants and heart problems, moment version is written by way of well-known specialists within the fields of atherosclerosis, center failure and antioxidants. it may be of curiosity to scientific scholars and fellows, researchers, and practising physicians. there was speedy development in our wisdom during this box over the last to 3 years. therefore the present reedition appears to be like well timed. for example, this moment version captures a number of lately suggested and released medical trials as welll as new info on diabetic and hypertensive heart problems.
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Additional resources for Antioxidants and Cardiovascular Disease (Developments in Cardiovascular Medicine), Second Edition
MPO has been identified in human atherosclerotic lesions and is of particular interest because lipid modifications found in human atherosclerosis bear similarities to hypochlorous acid-mediated derivation of lipoprotein constituents in vitro^^^\ Interestingly, a recent study showed that a single initial measurement of plasma myeloperoxidase levels in patients presenting to the emergency room with chest pain and negative troponin T levels independently predicted inhospital risk of myocardial infarction (MI), as well as the risk of major adverse cardiac events at 30-day and 6-month periods^^^\ However, in bone marrow transplantation experiments in which LDLR'^'mice received MPOdeficient bone marrow progenitor cells, larger lesions were observed than in LDLR"^' mice transplanted with wild type progenitor cells.
Arteriosclerosis 1987;7:135-43. Liao F, Andalibi A, Qiao JH et al. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J Clin Invest 1994;94:877-84. Sparrow CP, Parthasarathy S, Steinberg D. Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification. J Lipid Res 1988;29:745-53. Benz DJ, Mol M, Ezaki M et al. Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15lipoxygenase.
Kodama et al^^^^ subsequently cloned and sequenced the acetyl LDL receptor which was redesignated the scavenger receptor, type A, or SR-A. In vitro, chemical acetoacetylation or conjugation of LDL with malondialdehyde (MDA) or via aggregated platelets releasing MDA generates MDA-LDL, which is recognized by SR-A^^^'^^\ However, the concentrations of MDA needed to generate MDA-LDL in vitro seem to be significantly higher than could be achieved in vivo, although MDA-LDL epitopes are abundant in atherosclerotic lesions^^^"^^^ Lipoproteins and oxidation Ti Endothelial cells, smooth muscle cells or macrophages Native LDL > Acetyl LDL V oxLDL 1 i Slow \ Native LDLR (downregulated) Acetyl LDLR ^ SR-A (not downregulated) CD36.
Antioxidants and Cardiovascular Disease (Developments in Cardiovascular Medicine), Second Edition by Martial G. Bourassa, Jean-Claude Tardif